PER conditioning and influence of antimetabolites on long term memory

On-Demand

Presenting Author(s)

Yarira Ortiz-Alvarado, n/a

University of Puerto Rico
Bayamon, Puerto Rico

Co-Author(s)

LS

Luz Sanchez-Lopez

University of Puerto Rico
Bayamon, Puerto Rico
MD

Michael De Jesus-Soto

University of Puerto Rico
Bayamon, Puerto Rico
Mehmet Ali Döke

University of Puerto Rico in Rio Piedras
Wyomissing, Pennsylvania
EP

Esther Peterson

University of Puerto Rico
San Juan, Puerto Rico
Tugrul Giray

University of Puerto Rico
San Juan, Puerto Rico
Carlos A. Ortiz-Alvarado

University of Puerto Rico, Rio Piedras
Bayamon, Puerto Rico
FN

Fanfan Noel

University of Puerto Rico
San Juan, Puerto Rico

Mechanisms of memory formation are important because organisms, particularly in a group, depend on memory of events, interactions, and individuals. The memories and their use can extend from seconds to a lifetime. Memory consolidation is crucial for our understanding of several neurological diseases and disorders commonly observed in humans. Especially for long term memory consolidation multiple mechanisms extending from protein to RNA to DNA modifications have been elucidated. Interestingly, memory consolidation issues are reported in cancer patients going through chemotherapy that is known to hinder DNA repair. We tested whether DNA repair events preceded memory formation and the influence of antimetabolites on long term memory consolidation following a proboscis extension response (PER) conditioning assay in honey bees.