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ViewAttendees 10

PBT

Section Symposium

Insecticidal Proteins: From Discovery to Commercialization

16: Challenges in the ERA of new insecticidal proteins: A case study of mCry51 for Lygus control

Thursday, November 19, 2020
1:20 PM - 1:35 PM EST
Livestream
A hypothesis-based approach, consistent with the existing risk assessment paradigm, was developed to characterize the potential for adverse effects to non-target organisms (NTOs) and inform the environmental risk assessment (ERA) for MON 88702 cotton expressing a modified Cry51Aa2 insecticidal crystal protein targeting certain sucking insect pests. For this ERA, well-designed, tiered laboratory bioassays were coupled with higher tier tritrophic studies and a tier 4 field evaluation to generate comprehensive and complimentary data sets demonstrating that the hazard identified for Orius insidiosus in lower tier tests did not translate to effects under more realistic conditions. The results of the ERA demonstrate that MON 88702 is unlikely to pose a risk to O. insidiosus or other key beneficial taxa under cultivation conditions.